EFFECT OF ETHANOLIC EXTRACT OF TELFAIRIA OCCIDENTALIS LEAVES ON RBC COUNT, PCV AND HB CONCENTRATION IN ALBINO RATS

EFFECT OF ETHANOLIC EXTRACT OF TELFAIRIA OCCIDENTALIS LEAVES ON RBC COUNT, PCV AND HB CONCENTRATION IN ALBINO RATS

 

1Ojo, N. A., 1Adawaren, E. O., 1Tijjani, M.B., 1 Chongmobmi, M., 1 Ladan, M. K., 1Simon, J., 2Ndahi, J.J. and 1Bargu, J.S.

1Department of Veterinary Physiology,

Pharmacology And Biochemistry,

University of Maiduguri

2Department of Veterinary Microbiology and Parasitology

University of Maiduguri

Abstract

Telfairia occidentalis is a tropical vine grown in West Africa. It is highly reputed in traditional medicine. It is extensively cultivated in southern Nigeria especially by the Igbo tribe. It is dioecious, perennial and drought tolerant, and is usually grown trellised.  Ethanolic extract of Telfairia occidentalis was investigated for toxicityand effect on red blood cell count (RBC), Packed Cell Volume (PCV), and Hemoglobin concentration (Hb) in albino rats. Phytochemical screening and elemental analysis were carried out using standard procedures.Lorke’s method was used to evaluate the acute oral toxicity of T.occidentalis using twelve rats. Administration of 3200 mg/kg maximum dose did not produce mortality or general signs of toxicity for 24 hours. The subacute toxicity study was carried out on 20 rats divided into 4 groups of five rats each (i.e A, B, C, and D). GroupB, C and D were treated orally with the ethanolic extract using 200mg/kg, 400mg/kg and 600mg/kg respectively for 21days while group A received distilled water (ad-libitum) as control group. Blood samples were collected at the end of every week and analyzed for RBC, PCV and Hb concentration using standard procedures. The phytochemical screening revealed the presence of tannins, cardiac glycosides, saponins, flavonoids and alkaloids. The elemental analysis revealed the presence of sodium, sulphur, chlorine, iron, zinc, manganese and potassium. No death or signs of toxicity were noticed in the rats but there were significant increases (P<0.05, P<0.01) in the PCV and hemoglobin concentration values. Ethanolic extract of Telfairia occidentalisleaves could be said to have low toxicity and significantly increased RBC,PCV and hemoglobin concentration values in rats.

Key words: Telfairiaoccidentalis, Ethanolic extract, Toxicity, RBC PCV, Hb concentration.

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