EFFECT OF COPPER SULPHATE ON HAEMATOLOGICAL PARAMETERS AND INDICES IN RATS
* DIBILA, H.M1., TELTA, D1., OJO, N.A1., SIMON, J1., SAMBO, N3., SANDABE, U. K1. AND EGBE-NWIYI, T. N2.
1Department of Veterinary Physiology, Pharmacology and Biochemistry,Faculty of Veterinary Medicine, University of Maiduguri.
2Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri.
3Department of Human Physiology, College of Medical Sciences, University of Maiduguri.
A total of one hundred albino rats of both sexes were used for the experiment to determine the effect of copper sulphate on the red blood cell count(RBC), packed cell volume(PCV), haemoglobin concentration(Hb), mean corpuscular volume(MCV), mean corpuscular haemoglobin(MCH) and mean corpuscular haemoglobin concentration(MCHC). The experiment lasted for a period of twenty one days and then the animals where observed for two weeks for post treatment effect. The rats were divided into four groups A, B, C and D of twenty five rats each. Five per cent (5%) concentration of copper sulphate was used. Graded doses of 25mg/kg, 50mg/kg and 100 mg/kg of copper sulphate were administered daily to groups A, B and C respectively by gastric intubation for a period of twenty one days. The rats in group D served as a control. Blood samples were collected for haematological parameters. The results of the investigations for the period of study on haematological parameters showed a significant (P<0.05) increase in RBC, Hb and PCV,(at dose 100mg /kg of copper sulphate on day 21 of the experiment), MCV, MCH and MCHC (all on days 14 and 21 of the experiment). During the withdrawal period there was also a significant (p<0.05) increase in RBC, Hb and PCV, but there was no significant (p<0.05) increase in MCV, MCH and MCHC. It may therefore be concluded that copper sulphate probably improves blood parameters of rats and thus probably acts as blood enhancer and haematinic.
Keywords: Copper Sulphate, Haematological Parameters, Indices, Rats